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. 2015 Apr 21;26(10):2349–2360. doi: 10.1681/ASN.2014070710

Figure 5.

Figure 5.

MSC-Dsh treatment induced in the kidney a different gene expression signature with respect to MSC-CTRL. (A) Pearson correlation of the global transcriptome profile of kidneys of healthy, untreated AKI, and AKI treated with MSC-CTRL, MSC-Dsh, EV-CTRL, and EV-Dsh mice. EV-CTRL and MSC-CTRL clustered into two major groups, supporting an overlap in the genes regulated by both cells and EVs in AKI. Moreover, healthy mice significantly correlated with MSC-CTRL and EV-CTRL samples. On the contrary, the transcriptomic profile of MSC-Dsh– and EV-Dsh–treated mice showed a high correlation with the untreated AKI mice. (B) Heat map of the distribution of AKI-deregulated genes in MSC-CTRL, MSC-Dsh, EV-CTRL, and EV-Dsh samples (n=2663 upregulated AKI versus healthy; n=1893 downregulated AKI versus healthy). (C) Median distribution of the FCs in MSC-CTRL, MSC-Dsh, EV-CTRL, and EV-Dsh with respect to AKI samples showing statistically different global distribution of all genes in two groups. FC, fold change.