Figure 10.

Prior ultrasound protects mice from AKI in a CLP model of sepsis but does not protect in α7nAChR^–/– mice. Mice were exposed to ultrasound (US) 24 hours before CLP and were euthanized 24 hours after CLP. (A) US reduced plasma creatinine in WT mice but α7nAChR^–/– mice were resistant to the protective effects. **P<0.001. (B) Hematoxylin and eosin staining of kidney sections from WT mice. Scale bar is 100 μm. (C) Kim-1 mRNA expression in WT kidney relative to glyceraldehyde 3-phosphate (GAPDH). P=0.09. n=8–9 from two experiments. Circles and squares refer to the 2 groups, CLP and US+CLP, respectively.