Figure 4.

Symmetry, asymmetry, and stochasticity in kidney development. (A) Dendrogram for E13.5 wild-type kidney showing lineage of each tree. Colored ellipses outline four lobes in the upper and three lobes in the lower half of the kidney. These are defined by clusters of associated nodes and branch segments, are conserved in all kidneys studied, and correlate with kidney anatomy. (B) The dendrogram adjusted radially to show two-dimensional lobe arrangement. (C) The average number of tips present within each lobe is indicated. n=4 kidneys, each extracted from each of four (identically aged) littermates at E13.5.