Table 1. PAH subject clinical characteristics and RV function.
Subjects | Age | Sex | ERA | PDE5 | CCB | PGI2 analogue | Functional Class | RVEF (%) |
---|---|---|---|---|---|---|---|---|
PAH01 | 42 | F | - | sildenafil 20 mg | nifedipine 30mg | - | II | 50 |
PAH02 | 29 | F | bosentan 125 mg | tadalafil 20 mg | amlodipine 5 mg | - | II | 53 |
PAH03 | 53 | F | ambrisentan 10 mg | - | amlodipine 2.5 mg | - | II | 54 |
PAH04 | 48 | M | ambrisentan 10 mg | tadalafil 20 mg | - | - | I | 40 |
PAH05 | 64 | F | bosentan 125 mg | sildenafil 20 mg | - | iloprost 20mcg/ml | I | 47 |
PAH06 | 26 | F | bosentan 125 mg | sildenafil 20 mg | - | - | I | 42 |
PAH07 | 29 | F | bosentan 62.5 mg | sildenafil 20 mg | - | - | I | 40 |
PAH08 | 20 | F | ambrisentan 10 mg | sildenafil 20 mg | - | - | I | 40 |
PAH09* | 27 | F | - | - | - | - | II | 41 |
PAH10 | 38 | M | - | sildenafil 20 mg | - | - | II | 45 |
Abbreviations: ERA = Endothelin receptor antagonists. PDE-5 = Phosphodiesterase Type 5 inhibitor. CCB = Calcium channel blocker. PGI2 = prostacyclin. All medications are taken in the usual dosing schedule. PAH09 was not on pulmonary hypertension specific medication due to chronic thromboembolic pulmonary hypertension before surgery.