Fig 8. I_MI counterbalances leak conductance to rescue neural oscillations in a computational model.

(A) Model output of LG membrane potential at (i) low leak and I_MI conductance (g _leak = 20 nS, ${\overline{g}}_{IMI}=80\text{\hspace{0.17em}ns}$), (ii) increased leak (g _leak = 40 nS, ${\overline{g}}_{IMI}=80\text{\hspace{0.17em}ns}$), and (iii) increased I_MI (g _leak = 40 nS, ${\overline{g}}_{IMI}=120\text{\hspace{0.17em}ns}$). Vertical scale bars, 20 mV. (B) Color map of number of bursts occurring in 100 s for 1,100 simulations as a function of leak and I_MI conductances. Warmer colors represent more bursts;* highlights areas with one burst. (C) Color map of the number of LG spikes/100 s for 1,100 simulations as a function of leak and I_MI conductances. Warmer colors represent more LG spikes. (B–C) Labeled areas (i–iii) indicate parameter sets corresponding to the traces shown in A.