Table 4.

Univariate and Multivariate results for overall survival (Discovery cohort)

A. Case–control approach
Parameter	Univariate analysis		Multivariate analysis
	HR (95 % CI)	p-value	HR (95 % CI)	p-value
Risk score	2.44 (1.28 – 4.68)	0.01	2.71 (1.38 – 5.35)	0.004
Tumor stage	0.42 (0.22 – 0.81)	0.01	0.36 (0.18 – 0.74)	0.01
Tumor grade	1.93 (0.99 – 3.75)	0.05
Age at diagnosis	1.05 (1.02 – 1.09)	0.003	1.04 (1.01 – 1.07)	0.02
TNBC status	0.88 (0.43 – 1.77)	0.71
B. Case-only approach
Parameter	Univariate analysis		Multivariate analysis
	HR (95 % CI)	p-value	HR (95 % CI)	p-value
Risk score	2.48 (1.34 – 4.61)	0.004	2.76 (1.47 – 5.19)	0.002
Tumor stage	0.42 (0.22 – 0.81)	0.01	0.37 (0.19 – 0.72)	0.004
Tumor grade	1.93 (0.995 – 3.75)	0.05
Age at diagnosis	1.05 (1.02 – 1.09)	0.003
TNBC status	0.88 (0.43 – 1.77)	0.71

A and B: The four and 11 miRNAs from Table 1A and B respectively were used to construct risk scores. Receiver Operating Characteristics Curve was used to dichotomize cases into low and high-risk groups. Univariate Cox proportional hazards regression model was run for risk score and for other clinical parameters. In the multivariate analysis, risk score was significant with p < 0.05 after adjusting for confounders.

HR Hazard Ratio; CI Confidence Interval; TNBC Triple Negative Breast Cancer