Table 4.
A. Case–control approach | ||||
Parameter | Univariate analysis | Multivariate analysis | ||
HR (95 % CI) | p-value | HR (95 % CI) | p-value | |
Risk score | 2.44 (1.28 – 4.68) | 0.01 | 2.71 (1.38 – 5.35) | 0.004 |
Tumor stage | 0.42 (0.22 – 0.81) | 0.01 | 0.36 (0.18 – 0.74) | 0.01 |
Tumor grade | 1.93 (0.99 – 3.75) | 0.05 | ||
Age at diagnosis | 1.05 (1.02 – 1.09) | 0.003 | 1.04 (1.01 – 1.07) | 0.02 |
TNBC status | 0.88 (0.43 – 1.77) | 0.71 | ||
B. Case-only approach | ||||
Parameter | Univariate analysis | Multivariate analysis | ||
HR (95 % CI) | p-value | HR (95 % CI) | p-value | |
Risk score | 2.48 (1.34 – 4.61) | 0.004 | 2.76 (1.47 – 5.19) | 0.002 |
Tumor stage | 0.42 (0.22 – 0.81) | 0.01 | 0.37 (0.19 – 0.72) | 0.004 |
Tumor grade | 1.93 (0.995 – 3.75) | 0.05 | ||
Age at diagnosis | 1.05 (1.02 – 1.09) | 0.003 | ||
TNBC status | 0.88 (0.43 – 1.77) | 0.71 |
A and B: The four and 11 miRNAs from Table 1A and B respectively were used to construct risk scores. Receiver Operating Characteristics Curve was used to dichotomize cases into low and high-risk groups. Univariate Cox proportional hazards regression model was run for risk score and for other clinical parameters. In the multivariate analysis, risk score was significant with p < 0.05 after adjusting for confounders.
HR Hazard Ratio; CI Confidence Interval; TNBC Triple Negative Breast Cancer