Table 5.
A. Case–control approach | ||||
Parameter | Univariate analysis | Multivariate analysis | ||
HR (95 % CI) | p-value | HR (95 % CI) | p-value | |
Risk score | 1.95 (1.16 – 3.29) | 0.01 | 2.27 (1.33 -3.88) | 0.003 |
Tumor stage | 0.42 (0.23 – 0.76) | 0.01 | 0.34 (0.18 – 0.65) | 0.001 |
Tumor grade | 1.52 (0.88 – 2.63) | 0.14 | ||
Age at diagnosis | 1.02 (0.99 – 1.05) | 0.29 | ||
TNBC status | 0.75 (0.39 – 1.41) | 0.37 | ||
B. Case-only approach Parameter | ||||
Parameter | Univariate analysis | Multivariate analysis | ||
HR (95 % CI) | p-value | HR (95 % CI) | p-value | |
Risk score | 1.68 (0.99 – 2.82) | 0.05 | 1.85 (1.09 – 3.14) | 0.02 |
Tumor stage | 0.42 (0.23 – 0.79) | 0.01 | 0.38 (0.20 – 0.71) | 0.003 |
Tumor grade | 1.52 (0.88 – 2.63) | 0.14 | ||
Age at diagnosis | 1.02 (0.99 – 1.05) | 0.29 | ||
TNBC status | 0.75 (0.39 – 1.41) | 0.37 |
A and B: The two and four miRNAs from Table 2A and B respectively were used to construct risk scores. Receiver Operating Characteristics Curve was used to dichotomize samples into low and high-risk groups. Univariate Cox proportional hazards regression model was run for risk score and for other clinical parameters. In the multivariate analysis, risk score was significant with p < 0.05 after adjusting for confounders.
HR Hazard Ratio; CI Confidence Interval; TNBC Triple Negative Breast Cancer