Consequences of eosinophil restoration following transfer of bone marrow cells. (A) (a) Lung resistance following bone marrow cell transfer and 7 OVA challenges. (b) BAL cell composition. (c) Lung resistance following bone marrow cell transfer and 11 OVA challenges. (d) BAL cell composition after 11 OVA challenges. (B) Goblet cell metaplasia. Representative photomicrographs in the lung tissue from (a) vehicle-treated WT mice after sensitization and 11 OVA challenges, (b) vehicle-treated PHIL mice after sensitization and 11 OVA challenges, (c) PHIL mice which received bone marrow cells from WT mice after sensitization and 11 OVA challenges, (d) PHIL mice which received bone marrow cells from IL-10−/− mice after sensitization and 11 OVA challenges, and (e) Quantitation of PAS-positive areas along the airways. (C) BAL fluid cytokine levels following bone marrow cell transfer and 11 OVA challenges. n=9 in all experiments except panel B-e (n=6). *p<0.05 vs. PHIL OVA/OVA-7+vehicle group, #p<0.05 vs. WT OVA/OVA-11+vehicle and PHIL OVA/OVA-11+ WT-BM.