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. 2015 Sep 29;11(9):e1005532. doi: 10.1371/journal.pgen.1005532

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© 2015 Chang et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 3 — (A) PCR analysis of genomic DNA in the neighborhood of Astn2 exon 5, as shown in Fig 2E. The ~30 kb deletion is present in 129X1/SvJ mice and R1 ES cells, but is absent from C57Bl6/J, 129S1/SvlmJ, and 129S6/SvEvTac mice. (B) The Astn2 locus from the three 129 mouse lines shown in (A) was bred to homozygosity in a Fz6 ^-/- background. The ridge phenotype was observed only in the presence of the 129X1/SvJ Astn2 locus; mice were photographed at P14.