Skip to main content
. 2015 Sep 16;2015:805876. doi: 10.1155/2015/805876

Table 1.

Aetiopathogenesis of neurotrophic keratitis.

Infections Herpes simplex
Herpes zoster
Leprosy [16]

Corneal pathologies Dystrophies
(i) Lattice
(ii) Granular

Iatrogenic injury Contact lens wear
Surgeries
Laser-assisted in situ keratomileusis [17]
Corneal incision [18]
Lamellar and penetrating keratoplasty

Topical medications Anaesthetics
Timolol
Betaxolol
Trifluridine
Sulfacetamide
Diclofenac sodium [19]

Toxic substances Chemical burns
Exposure to oleoresin capsicum pepper spray [20]
Exposure to hydrogen sulfide (H2S) [21]

Cranial nerve V palsy Trigeminal neuralgia surgery
Neoplasm
Aneurysm
Facial trauma [10]
Congenital: 
(i) Riley-Day syndrome
(ii) Möbius corneal hypoesthesia
(iii) Goldenhar syndrome
(iv) Familial corneal hypesthesia
(v) (Familial trigeminal anesthesia)
(vi) Congenital insensitivity to pain with anhidrosis

Systemic diseases Diabetes
Vitamin A deficiency
Multiple sclerosis

Miscellaneous Increasing age
Adie's syndrome [22]