Table 1.
Infections | Herpes simplex Herpes zoster Leprosy [16] |
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Corneal pathologies | Dystrophies (i) Lattice (ii) Granular |
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Iatrogenic injury | Contact lens wear Surgeries Laser-assisted in situ keratomileusis [17] Corneal incision [18] Lamellar and penetrating keratoplasty |
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Topical medications | Anaesthetics Timolol Betaxolol Trifluridine Sulfacetamide Diclofenac sodium [19] |
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Toxic substances | Chemical burns Exposure to oleoresin capsicum pepper spray [20] Exposure to hydrogen sulfide (H2S) [21] |
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Cranial nerve V palsy | Trigeminal neuralgia surgery Neoplasm Aneurysm Facial trauma [10] Congenital: (i) Riley-Day syndrome (ii) Möbius corneal hypoesthesia (iii) Goldenhar syndrome (iv) Familial corneal hypesthesia (v) (Familial trigeminal anesthesia) (vi) Congenital insensitivity to pain with anhidrosis |
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Systemic diseases | Diabetes Vitamin A deficiency Multiple sclerosis |
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Miscellaneous | Increasing age Adie's syndrome [22] |