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. 2015 Aug 21;4(3):406–426. doi: 10.3390/cells4030406

Figure 3.

Figure 3

Patterns of temporal regulation of nuclear transport. (A) A schematic of the nuclear transport cycle of shuttling proteins. (B) An example of the regulation of the nuclear export. Temporal accumulation of cargo proteins can be achieved by shutting off the nuclear export through modification to the NES in cargos. (C) An example of the regulation of the nuclear import. Temporal accumulation of cargo here is due to acceleration of import through modification to the NLS of cargos; (D) An example of the regulation of nucleoporins (Nups). Phosphorylation of the nuclear pore complex (NPC) component blocks the nuclear import as importin is trapped at the NPC.