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. 2015 Sep 18;4(3):538–568. doi: 10.3390/cells4030538

Figure 3.

Figure 3

Structural changes of CRM1 between the extended and compact conformation. Structural overview illustrating the conformational changes of CRM1 during an export cycle. The conformations depicted here thus highlight the changes in two conformational states of CRM1 (grey) with respect to the overall shape (extended versus compact) as well as the positional changes of the CRIME-domain (green), the acidic loop (blue), the C-terminal helix (HEAT helix 21B, red) and the conformation of the NES-binding cleft (orange) during the transport cycle. See main text for details.