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Substaging of intermediate-stage; Bolondi substaging system
| Intermediate substage | B1 | B2 | B3 | B4 |
| Child-Pugh score | 5-7 | 5-6 | 7 | 8-9 |
| Up-to-7 criterion | In | Out | Out | Any |
| 1st option | TACE | TACE or TARE | BSC | |
| Alternative | LT | Sorafenib | Research trial | LT |
| TACE + Ablation | TACE | |||
| Sorafenib | ||||
| Median survival time (mo) | 41.0 | 22.1 | 14.1 | 17.2 |
