Table 1.
Probiotics as adjuvant therapy in Helicobacter pylori eradication protocols
| Ref. |
Therapy |
Study |
Eradication rate |
Adverse effects |
||||
| Eradication therapy (d) | Probiotic therapy (d) | No. pts | Reass. of H. pylori | H. pylori + probiotic therapy | H. pylori therapy | H. pylori + probiotic therapy | H. pylori therapy | |
| Cindoruk et al[79] | PPI + AC (14) | S. boulardii (14) | 124 | UBT | 44/621 | 37/62 | 14/621 | 37/62 |
| Cremonini et al[71] | PPI + CT (7) | S. boulardii (14) | 43 | UBT | 17/20 | 16/20 | 3/211 | 12/20 |
| Duman et al[80] | PPI + AC (14) | S. boulardii (14) | 389 | - | - | - | 17/2041 | 31/185 |
| Hurduc et al[81] | PPI + AC (10) | S. boulardii (28) | 90 | UBT, hist. | 45/48 | 34/42 | 4/481 | 13/42 |
| Song et al[65] | PPI + AC (7) | S. boulardii (28) | 661 | UBT | 264/330 | 237/331 | 48/3301 | 63/331 |
| Zojaji et al[66] | PPI + AC (14) | S. boulardii (14) | 160 | UBT | 75/80 | 65/80 | 14/801 | 29/80 |
| Canducci et al[67] | PPI + AC (7) | L. acidophilus (7 ) | 120 | UBT | 42/601 | 52/60 | - | - |
| Sýkora et al[69] | PPI + AC (7) | L. casei (14) | 86 | UBT | 33/391 | 27/47 | 7/39 | 9/47 |
| Armuzzi et al[68] | PPI + CT (7) | L. GG (14) | 60 | UBT | 25/30 | 24/30 | 12/301 | 20/30 |
| Szajewska et al[70] | PPI + AC (7) | L. GG (14) | 83 | UBT, hist., RUT | 23/34 | 22/32 | 18/35 | 13/32 |
| Cremonini et al[71] | PPI + CT (7) | L. GG (14) | 85 | UBT | 16/21 | 16/20 | 3/201 | 12/20 |
| Ojetti et al[72] | PPI + AL | L. reuteri (14 ) | 90 | UBT | 36/451 | 27/45 | 10/451 | 26/45 |
| Lionetti et al[73] | PPI + ACT (10) | L. reuteri (20 ) | 42 | UBT | 17/20 | 16/20 | 3/201 | 9/20 |
| Francavilla et al[57] | PPI + (7) | L. reuteri (2 strains) (60) | 100 | UBT | ||||
| Emara et al[74] | PPI + AC (14) | L. reuteri (28) | 70 | hist., RUT | 26/35 | 23/35 | 10/351 | 24/35 |
| Sheu et al[75] | PPI + AC (7) | B. animalis, L. casei (35) | 160 | hist., RUT, UBT | 73/801 | 63/80 | 15/801 | 53/80 |
| Goldman et al[76] | PPI + AC (7) | B. animalis, L. casei (90) | 65 | UBT | 14/33 | 13/32 | - | - |
| Deguchi et al[77] | PPI + AC (7) | L. gasseri (28) | 229 | UBT | 95/1111 | 79/106 | - | - |
| Nista et al[78] | PPI + AC (7) | B. clausii (14) | 120 | UBT | 39/50 | 37/50 | 21/501 | 30/50 |
1
Statistically significant (P < 0.05). -: Data are not available; p: Pediatric study; Pts.: Patients; Reass.: Reassessment; PPI: Proton pump inhibitor: UBT: Urea breath test; Hist.: Histology; RUT: Rapid urease test; A: Amoxicillin; C: Clarithromycin; T: Tinidazole; L: Levofloxacin.