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. 2014 Oct 28;52(3):1421–1429. doi: 10.1007/s12035-014-8917-0

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© The Author(s) 2014

Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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Fig. 3 — Social isolation during adolescence facilitates the induction of L-LTP. a, d Normalized fEPSP slope is plotted from control slices (open circles) and isolated slices (closed circles). Arrow indicates 1*HFS (100 Hz, 1 s) tetanus stimulation in A and 4*HFS (100 Hz, 1 s with 10-s interval) in d. b, e Histogram showing average percentage of potentiation after tetanus versus baseline (100 %) at control and isolated mice. Left showed the comparing between the E-LTP (40–50 min after tetanus versus baseline) of the two groups; right showed the comparing between the L-LTP (170–180 min after tetanus vs baseline). c, f Adolescence social isolation does not shift I-O curve. Input/output curve of fEPSP (mV/ms) versus stimulation intensity (mV) were taken from control and isolated mice. Vertical bars represent the mean ± SEM. Asterisks indicate significant differences from the relevant controls (***p < 0.001, two-tailed)