Fig. 5.

Acutely applied K-252a can rescue the facilitation of L-LTP in isolated mice. a Normalized fEPSP slope is plotted from control slices (open circles) and isolated slices (closed circles), and K-252a (200 nM) was applied starting 20 min before tetanus (closed circles). b Histogram showed average percentage of potentiation after tetanus versus baseline (100 %) at control and isolated slices. Left showed the comparing between the E-LTP (40–50 min after tetanus vs baseline) of the two groups; right showed the comparing between the L-LTP (170–180 min after tetanus vs baseline). c K-252a did not change the basal synaptic transmission. K-252a was applied 10 min after the beginning. Vertical bars represent the mean ± SEM