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. 2015 Sep 30;6:267. doi: 10.3389/fphys.2015.00267

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Copyright © 2015 Padilha, Henriques, Lopes-Pacheco, Abreu, Oliveira, Morales, Lima, Barreiro, Silva, Xisto and Rocco.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Flowchart and timeline of study design. Control (C), four intratracheal administrations of saline; Emphysema (E), four intratracheal administrations of porcine pancreatic elastase (PPE); DMSO, vehicle (dimethyl sulfoxide)—intraperitoneal treatment with DMSO for 8 days; LASSBio-596, intraperitoneal treatment with LASSBio-596 for 8 days. All data were analyzed on day 29.