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. 2015 Sep 30;6:267. doi: 10.3389/fphys.2015.00267

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Copyright © 2015 Padilha, Henriques, Lopes-Pacheco, Abreu, Oliveira, Morales, Lima, Barreiro, Silva, Xisto and Rocco.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Static lung elastance (Est,L) (A), mean linear intercept (Lm) (B), mononuclear cells, neutrophils, and total cells in lung tissue (C), and representative photomicrographs of lung parenchyma stained with hematoxylin-eosin. Note enlargement of alveolar space in the Egroup (arrow) (D). Presence of pulmonary emphysema on day 21 was analyzed in two groups (C,E). C, mice received intratracheal saline and were analyzed on day 21; E, mice received intratracheal porcine pancreatic elastase and were analyzed on day 21. ^*Significantly different from C (p < 0.05).