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. 2015 Sep 30;6:267. doi: 10.3389/fphys.2015.00267

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Copyright © 2015 Padilha, Henriques, Lopes-Pacheco, Abreu, Oliveira, Morales, Lima, Barreiro, Silva, Xisto and Rocco.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunohistochemical analysis for the M1 (A) and (B) M2 macrophage phenotypes in lung tissue. Values are means (± SD) of six animals in each group. C-DMSO: mice received intratracheal saline and were treated with DMSO. C-LASSBio-596 mice received intratracheal saline and were treated with LASSBio-596. E-DMSO: mice received intratracheal porcine pancreatic elastase and were treated with DMSO. E-LASSBio-596: mice received intratracheal porcine pancreatic elastase and were treated with LASSBio-596. ^*Significantly different from respective group C (p < 0.05). ^#Significantly different from E-DMSO (p < 0.05).