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PEA-15 phosphorylation cycle. Ser104 is phosphorylated by PKC, and Ser116 is phosphorylated by CaMKII or PKB/Akt. PP2A is indicated to dephosphorylate p-Ser104, while PP4 is associated with dephosphorylation at p-Ser116. PTEN reduces p-Ser116 content by deactivating Akt. The relative protein kinase/phosphatase activities mediate PEA-15 phosphorylation homeostasis.
