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. 2015 Aug 10;125(9):3532–3544. doi: 10.1172/JCI81749

Figure 8. PRMT5 loss impairs the cell surface expression of cytokine receptors.

Figure 8

(A) BM cells were isolated from day-7 control and Prmt5-KO mice and stained for HSPC markers and several cytokine receptors. Percentages of FLT3-, IL-6Rα–, and IL-3Rα–positive cells in LK and LSK cell populations were plotted. (B and C) Day-7 control and Prmt5-KO BM cells were stained for HSPC cell surface marker expression and subjected to FACS analysis. Representative histogram shows decreased c-Kit expression in day-7 PRMT5-null HSPCs (B). The MFI of c-Kit staining in control and PRMT5-null LK and LSK cells was plotted as the mean ± SD (n = 5) (C). P values were determined by a 2-tailed Student’s t test.