Effect of MP-MUS on mitochondrial membrane potential, mtDNA, and MAOB.
(A) Glioma incubated ± MP-MUS and ± selegiline for 24 h show mitochondrial damage and upregulation of MAOB only when uninhibited MAOB is incubated with MP-MUS. MP-MUS/MAOB induces a drop in ΔΨ, an increase in fpg-sensitive mtDNA lesions, and an elevation of MAOB levels.
(B) Effects of MP-MUS with respect to time; the first changes in mitochondrial function, ΔΨ, and damage are observed after 30 min and continue up to 24 h.
(C) The data presented in A and B is shown as a plot. All changes reported are at p < 0.05, except fpg-sensitive DNA lesions at 2 h (‡), mean ± SEM, n = 8.