Fig. 6.

Alteration in glioblastoma phenotype after MP-MUS treatment.

(A) Representative images of the two cell lineages treated ± MP-MUS show an increase in steady state of MAOB levels, mtDNA lesions and permanent changes in the generation of reactive oxygen species.

(B) Graphical representations of the altered phenotypes are shown with significant changes in levels of MAOB, the mtDNA breaks, peroxides and hydroxyl radical. ** p < 0.01 and *** p < 0.005 at the n = number of individual wells shown in the insert.

(C) High resolution images of blunt ended DNA breaks (green) and DNA (blue) of cells grown from xenografts. Blunt-ended DNA is non-nuclear, cytosolic mtDNA with some invaginations of cytosol into the nucleus.