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. 2015 Sep 23;6:446–453. doi: 10.1016/j.redox.2015.09.008

Fig. 3.

Fig. 3

M-CSF stimulation of PAMM expression requires Akt phosphorylation. Human CD14+ PBMCs were stimulated with M-CSF (+) and Wortmannin (W) or Rapamycin (R) for 4 days. M-CSF induced PAMM expression and phosphorylation of Akt (Ser 473). Wortmannin and Rapamycin, on the other hand, blocked M-CSF-induced Akt phosphorylation and PAMM expression. (−): Untreated control cells. (+): Cells stimulated with 150 ng/mL M-CSF. W: Cells stimulated with M-CSF and 100 nM Wortmannin. R: Cells stimulated with M-CSF and 100 nM Rapamycin.