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Indices of increased dopaminergic regulators in the VTA of HOM wheel-runners. (A) ObRb, (B) Drd1a, (C) Drd2, (D) Th, (E), Slc6a3, and (F) Oprk1 gene expression in the ventral tegmental area of WT and HOM littermate rats without (sedentary) or with (runner) free access to running wheels for 5 wk (n = 5–6/group). All data are represented relative to WT sedentary controls. Different letters indicate significant difference as following: a,bp < 0.05, genotype × treatment interaction.
