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. 2015 Jul 17;4(10):692–705. doi: 10.1016/j.molmet.2015.07.003

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© 2015 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Moderate voluntary exercise decreases hyperleptinemia and normalizes hypercholesterolemia and hepatic steatosis in HOM rats. (A) Plasma leptin, (B) correlation analysis of final body weight and plasma leptin, (C) plasma insulin, (D) plasma triglycerides (TG), (E) plasma cholesterol, (F) liver lobe weight, (G) hepatic TG levels (n = 7/group), and hepatic (H) Scd1 mRNA expression (n = 12–14/group) of WT and HOM rats without (sedentary) or with (runner) free access to running wheels for 5 wk. Different letters indicate significant difference as following: ^a,b,cp < 0.05, genotype × treatment interaction; ^d,ep < 0.05, effect of treatment; ^f,gp < 0.05, effect of genotype.