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. 2015 Aug 6;4(10):741–752. doi: 10.1016/j.molmet.2015.07.007

Figure 3.

Figure 3

Metabolic characterization of ApoE−/−TIMP3−/− mice reveals impaired lipid oxidation. A) Analysis of fasting glucose levels reveals significant reduction in ApoE−/−TIMP3−/− mice (***p < 0.001, Student's t test, n = 14 for ApoE−/− and n = 6 for ApoE−/−TIMP3−/− per group). B) Intraperitoneal Glucose Tolerance test shows no significant differences between the two groups (n = 14 for ApoE−/− and n = 6 for ApoE−/−TIMP3−/− per group). C) Mild insulin resistance of ApoE−/−TIMP3−/− mice at the Insulin Tolerance Test (*p < 0.05, Student's t test, n = n = 4 for ApoE−/− and n = 5 for ApoE−/−TIMP3−/− per group). D) Indirect calorimetry of ApoE−/−TIMP3−/− compared to ApoE−/− mice during 12 consecutive hours of fasting conditions. Data show the interval from 8 to 12 h of fasting. RER was significantly increased and lipid oxidation significantly reduced in ApoE−/−TIMP3−/− mice (*p < 0.05, Student's t test, n = 3–4).