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. 2014 Nov 25;6(4):e982949. doi: 10.4161/19382014.2014.982949

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© 2014 The Author(s). © 2014 Published with license by Taylor & Francis Group, LLC

© Matthew Riopel, Jinming Li, George F Fellows, Cynthia G Goodyer, and Rennian Wang

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 6. — Glucagon signals present in somatostatin and pancreatic polypeptide granules. Double immunogold staining reveals glucagon (10 nm, arrows) and somatostatin (20 nm, arrowheads) (A, left panel) or pancreatic polypeptide (20 nm, arrowheads) (A, right panel) positivity in a single endocrine cell granule in a 14 week human fetal pancreas. Highlighted areas are enlarged in (A1). Scale bar = 250 nm. (B) Triple immunofluorescence staining of pancreatic polypeptide (blue), somatostatin (green) and glucagon (red) reveals specific cells positive for multiple hormones (arrows) in the 14 weeks fetal pancreas. Highlighted area is enlarged in far right panel, scale bar = 50 μm. N = nucleus, PP = pancreatic polypeptide granules, S = somatostatin granules. Representative images from 8–10 pancreata are shown.