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. 2015 Jun 1;7(1):e1027854. doi: 10.1080/19382014.2015.1027854

Figure 8.

Figure 8.

Overexpression of AURKA maintains Glucose Stimulated Insulin Secretion. (A) Glucose stimulated insulin secretion was measured 96 h after transduction with AdCMV-GFP, AdCMV-Nkx6.1 or AdCMV-AURKA in media containing 2.5 mM Glucose and 16.7 mM Glucose for 1 h. (B) Glucose stimulated insulin secretion was measured 96 h after transduction with AdCMV-GFP, AdCMV-Nkx6.1 or AdCMV-AURKA and 72 h after treatment with the AURKA inhibitor VX-680 in media containing 2.5 mM Glucose and 16.7 mM Glucose for 1 h. Data represent the mean ± SEM of 4 independent experiments. *P ≤ 0.05. P value represents the comparison between Nkx6.1- and GFP-treated islets.