Figure 9.

Overexpression of AURKA results in decreased p53 protein levels. (A) Islets were transduced with AdCMV-GFP or AdCMV-AURKA, and protein levels of GFP, AURKA, Cyclin A2, Cyclin B1 and p53 were measured 72 h after adenoviral transduction. Representative western blots from 4 independent experiments. (B) Islets were either untreated or transduced with AdCMV-GFP or AdCMV-AURKA. Islets were treated with MG-132 at 68 h after adenoviral transduction, and islets were harvested for western blotting 4 h later. Representative western blots from 3 independent experiments. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001.