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The in vivo antitumor activity of DOX loaded DOX-hyd-PEG-ALN micelles on tumor-bearing nude mice. Tumor-bearing nude mice recorded by camera at the end of treatment (A); tumor volume changes (B, *P < 0.05 vs DOX; #P < 0.05 vs control); tumor inhibition rate (C, *P < 0.05 vs DOX at the same time point); body weight changes (D, *P < 0.05 vs DOX); survival curve (E, *P < 0.05 vs DOX; #P < 0.05 vs control); H&E staining of tumor and heart tissue section from tumor bearing nude mice (F).
