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. 2015 Sep 30;35(39):13448–13462. doi: 10.1523/JNEUROSCI.5038-14.2015

Figure 2.

Figure 2.

Network deafferentation leads to reduction of seizure threshold. A, Raster plot of activity in control network without deafferentation. Brief 1 s stimulus was applied at 300 s (red bar). B, Single-cell activity from control network in A (location indicated by arrow). C, Zoom-in of activity from B showing spontaneous firing pattern. D, Raster plot of activity of a network with 50% deafferentation applied at 100 s (green triangle). Stimulation was applied at 300 s (red bar) of equal duration and strength as that applied in A. E, Single-cell activity from the deafferented network in D. F, Left, synchronized bursting events with spike inactivation during spike and wave seizure-like activity in E. Right, Background bursting firing pattern generated between seizures. G, Left, LFP of the network corresponding to the spike and wave epileptiform activity shown in F (left). Right, the LFP corresponding to background bursting in F (right).