Table 2.
Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) determination for 21 persister mutants and the parent strain E. coli W3110 using different antibiotics∗.
| MIC/MBC (mg/L) | ||||
|---|---|---|---|---|
| Strains | Ampicillin | Gentamicin | Norfloxacin | Trimethoprim |
| ΔglpD | 6.25/25 | 2.5/2.5 | 0.125/0.125 | 0.5/2 |
| ΔrelA | 6.25/12.5 | 1.25/1.25 | 0.125/0.125 | 0.5/2 |
| ΔuvrA | 12.5/25 | 1.25/2.5 | 0.125/0.125 | 0.5/2 |
| ΔumuD | 6.25/12.5 | 2.5/5 | 0.25/0.5 | 0.25/1 |
| Δlon | 6.25/12.5 | 2.5/2.5 | 0.25/0.25 | 0.5/4 |
| ΔrelE | 6.25/12.5 | 2.5/2.5 | 0.125/0.125 | 0.125/0.5 |
| ΔsmpB | 6.25/6.25 | 1.25/2.5 | 0.06/0.25 | 0.125/0.25 |
| ΔssrA | 6.25/6.25 | 2.5/2.5 | 0.06/0.25 | 0.25/1 |
| ΔdinJ | 12.5/25 | 2.5/5 | 0.125/0.125 | 0.5/2 |
| ΔrpoS | 12.5/25 | 1.25/1.25 | 0.25/0.25 | 0.5/4 |
| ΔtnaA | 6.25/12.5 | 2.5/2.5 | 0.125/0.125 | 0.5/1 |
| ΔpspF | 12.5/25 | 2.5/2.5 | 0.125/0.125 | 0.5/2 |
| ΔmqsR | 6.25/12.5 | 2.5/2.5 | 0.25/0.25 | 0.5/2 |
| ΔclpB | 12.5/25 | 1.25/2.5 | 0.125/0.25 | 0.06/0.25 |
| ΔphoU | 3.13/6.25 | 1.25/1.25 | 0.06/0.125 | 0.25/1 |
| ΔhipA | 6.25/6.25 | 1.25/1.25 | 0.125/0.125 | 0.25/1 |
| ΔrecA | 6.25/12.5 | 1.25/2.5 | 0.125/0.125 | 0.25/2 |
| ΔtisAB | 3.13/6.25 | 1.25/1.25 | 0.125/0.125 | 0.25/1 |
| ΔsucB | 6.25/12.5 | 1.25/2.5 | 0.06/0.125 | 0.25/2 |
| ΔoxyR | 12.5/25 | 2.5/2.5 | 0.25/0.25 | 0.25/1 |
| ΔdnaK | 6.25/12.5 | 1.25/1.25 | 0.25/0.5 | 0.125/0.5 |
| W3110 | 6.25/12.5 | 2.5/2.5 | 0.125/0.125 | 0.5/2 |
∗The first value is MIC and the second value under ‘/’ refers to MBC.