Table 2.

Gene Expression Changes Observed After SMAD4 Expression in BxPC3

Comparison	Up (Number of Genes)	Down (Number of Genes)
8 h	221	91
8–24 h	264	233
24 h	566	536
24–48 h	105	49
48 h	707	524

Number of expression changes at each time point. Transcripts with a signal of greater than 50 in the pairwise comparison that showed more than or equal to 2-fold change in expression with a P < .05 are included. Comparisons: 8 hours is untreated vs 8 hours + doxycycline; 8–24 hours is 8 hours + doxycycline vs 24 hours + doxycycline; 24 hours is untreated vs 24 hours + doxycycline; 24–48 hours is 24 hours + doxycycline vs 48 hours + doxycycline; untreated vs 48 hours + doxycycline.