Table 6.
Top 25 (Log-Ratio) Up- and Down-Regulated Transcripts in BxPC3 24–48 Hours After SMAD4 Expression
| Gene ID | P Value | Log-Ratio | Accession |
|---|---|---|---|
| ESM1 | 3.31E-12 | −4.925 | NM_007036.2 |
| TNFRSF11B | 1.74E-12 | −1.890 | NM_002546.3 |
| STK32A | 5.92E-05 | −1.873 | NM_145001.2 |
| DKK4 | 3.88E-05 | −1.867 | NM_014420.2 |
| STC1 | 7.36E-38 | −1.823 | NM_003155.2 |
| CLDN10 | 7.85E-06 | −1.723 | NM_006984.3 |
| GNG11 | 2.49E-10 | −1.657 | NM_004126.3 |
| TMPRSS11D | 3.21E-10 | −1.637 | NM_004262.2 |
| CGA | 2.24E-15 | −1.541 | NM_000735.2 |
| SNORD16 | 1.54E-20 | −1.518 | NR_002440.1 |
| CDH15 | 8.00E-11 | −1.497 | NM_004933.2 |
| ARG2 | 1.93E-09 | −1.439 | NM_001172.3 |
| CDKN2C | 1.70E-08 | −1.412 | NM_078626.2 |
| SCG5 | 3.44E-07 | −1.387 | NM_003020.1 |
| PPP4R4 | 9.27E-04 | −1.376 | NM_020958.2 |
| LOC643272 | 1.36E-10 | −1.352 | XM_926633.1 |
| SLC7A2 | 6.58E-05 | −1.306 | NM_001008539.2 |
| SOCS1 | 3.01E-04 | −1.299 | NM_003745.1 |
| HS.574590 | 4.01E-03 | −1.237 | DA728582 |
| HS.211930 | 3.24E-03 | −1.182 | XM_374307 |
| LOC100130111 | 3.49E-12 | −1.173 | XM_001713911.1 |
| TM4SF19 | 4.59E-06 | −1.168 | NM_138461.2 |
| DHRS9 | 4.61E-03 | −1.159 | NM_005771.3 |
| LOC100131608 | 5.47E-04 | −1.146 | XM_001715126.1 |
| COL8A1 | 5.48E-09 | −1.136 | NM_020351.2 |
| TRIM22 | 2.26E-08 | 4.907 | NM_006074.3 |
| C1R | 2.70E-05 | 2.973 | NM_001733.4 |
| KRT23 | 7.44E-09 | 2.954 | NM_015515.3 |
| MUC20 | 1.27E-07 | 2.852 | NM_001098516.1 |
| SPRR2E | 7.24E-05 | 2.777 | NM_001024209.2 |
| SLC27A2 | 2.22E-08 | 2.483 | NM_003645.2 |
| KRT86 | 3.13E-07 | 2.426 | NM_002284.3 |
| IL1F9 | 2.22E-16 | 2.408 | NM_019618.2 |
| TNNC1 | 1.11E-06 | 2.185 | NM_003280.1 |
| MMP7 | 3.68E-38 | 2.062 | NM_002423.3 |
| KRT4 | 3.05E-12 | 2.036 | NM_002272.2 |
| KRT81 | 2.42E-10 | 2.015 | NM_002281.2 |
| PPP2R2B | 1.64E-14 | 2.013 | NM_181676.1 |
| OLFML2A | 3.68E-38 | 1.957 | NM_182487.2 |
| SLC1A3 | 3.68E-38 | 1.916 | NM_004172.3 |
| IL8 | 3.68E-38 | 1.836 | NM_000584.2 |
| FLJ41603 | 2.76E-07 | 1.831 | NM_001001669.2 |
| SAA1 | 2.61E-03 | 1.825 | NM_000331.3 |
| MUC1 | 3.68E-38 | 1.809 | NM_001044391.1 |
| SULT2B1 | 8.84E-05 | 1.797 | NM_004605.2 |
| SPRR2F | 1.02E-05 | 1.787 | NM_001014450.1 |
| CXXC5 | 3.68E-38 | 1.756 | NM_016463.7 |
| SPRR2D | 2.60E-14 | 1.756 | NM_006945.3 |
| ALDH3B1 | 5.43E-04 | 1.717 | NM_000694.2 |
| TRIM31 | 1.25E-05 | 1.709 | NM_007028.3 |
Most dramatically regulated genes between 24 and 48 hours after SMAD4 expression. Transcripts with a signal of greater than 50 in the pairwise comparison that showed more than or equal to 2-fold change in expression with a P < .05 are included sorted by log-ratio to include the top 25 down- and up-regulated transcripts.