TABLE 2.
Implantation |
Clinical pregnancy |
Live birth |
||||
Quartile (minimum–maximum) | Cases/cycles, % | RR (95% CI) | Cases/cycles, % | RR (95% CI) | Cases/cycles, % | RR (95% CI) |
Serum folate, ng/mL | ||||||
Q1 (9.7–16.5) | 22/45 (48.9) | 1.00 (ref) | 18/45 (40.0) | 1.00 (ref) | 14/45 (31.1) | 1.00 (ref) |
Q2 (16.6–20.2) | 20/35 (57.1) | 1.23 (0.85, 1.77) | 15/35 (42.9) | 1.02 (0.62, 1.67) | 10/35 (28.6) | 0.77 (0.38, 1.54) |
Q3 (20.3–26.3) | 23/39 (58.9) | 1.23 (0.90. 1.69) | 22/39 (56.4) | 1.35 (0.90, 2.02) | 17/39 (43.6) | 1.19 (0.68, 2.09) |
Q4 (26.4–154.2) | 22/35 (62.9) | 1.31 (0.89, 1.93) | 21/35 (60.0) | 1.50 (0.98, 2.32) | 18/35 (51.4) | 1.62 (0.99, 2.65) |
P-trend | 0.26 | 0.04 | 0.01 | |||
Serum vitamin B-12, pg/mL | ||||||
Q1 (162–438) | 25/43 (58.1) | 1.00 (ref) | 20/43 (46.5) | 1.00 (ref) | 12/43 (27.9) | 1.00 (ref) |
Q2 (439–534) | 23/46 (50.0) | 0.89 (0.62, 1.28) | 20/46 (43.5) | 0.92 (0.61, 1.39) | 16/46 (34.8) | 1.19 (0.67, 2.10) |
Q3 (535–701) | 15/32 (46.9) | 0.82 (0.53, 1.27) | 14/32 (43.8) | 0.91 (0.57, 1.46) | 11/32 (34.4) | 1.13 (0.57, 2.24) |
Q4 (702–2176) | 24/33 (72.7) | 1.31 (0.95, 1.80) | 22/33 (66.7) | 1.43 (0.98, 2.08) | 20/33 (60.6) | 2.04 (1.14, 3.62) |
P-trend | 0.03 | 0.01 | 0.008 |
All analyses were conducted by using generalized estimating equations with binomial distribution and log link function with adjustment for age (continuous), BMI (continuous), and race (white, other). Tests for trend across quartiles were conducted by using a variable with the median serum concentration in each quartile as a continuous variable. Q, quartile; ref, reference.