Table 2.

Clinical outcomes

	PFS		TTBM		OS From Primary Diagnosis		OS From Brain Metastasis
	HR	P	HR	P	HR	P	HR	P
Primary tumor
HER2 IHC/FISH positivea	1.0	.89	1.0	1.0	0.95	.86
HERmark positive (H2T)b	1.5	.27	1.5	.20	1.8	.11
P95 positive	2.2	.013	1.8	.070	2.1	.042
Brain metastasis
HER2 IHC/FISH positive			1.3	.37			0.97	.93
HERmark positive (H2T)			1.3	.31			1.2	.63
P95 positive			2.0	.016			1.2	.61

Abbreviations: HR, hazard ratio; OS, overall survival from time of diagnosis of primary tumor or brain metastasis.

All results stratified by hormone receptor status and tumor grade.

^aEither HER2 IHC 3+ or HER2 FISH positive.

^bHERmark H2T >17.8 RF/mm².