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Immunostaining for 5 key enzymes of the kynurenine pathway in a grade I and grade III meningioma. Both tumors showed TDO2>IDO2>IDO1 immunostaining. Between the 2 downstream enzymes, KYNU showed stronger staining as compared with KMO. The grade III meningioma showed overall weaker immunostaining for the same enzymes as compared with the grade I tumor. Original magnification 20×. The length of the scale bar is 50 μm and applies to all images.
