Figure 1.

Genetic inactivation of Klf11 leads to alteration in glucose homeostasis under normal feeding conditions. Klf11 WT (Klf11+/+) and Klf11 whole-body knockout (Klf11−/−) female mice fed with normal chow diet were challenged with ip injection of glucose (1.5 mg/kg) (A) for GTT, insulin (0.1 U/kg) (B) for ITT, or sodium pyruvate (1.5 mg/kg) (C) for PTT. Blood glucose was measured from the tail vein at different times after injection (0, 20, 30, 60, and 120 min). For each mouse, the AUC was calculated and the average plotted on the right. In all cases, food was removed 6 hours before performing the test. Tests were performed with 10 mice per group (*, P < .05, t test).