Table 2.

Blood and Tissue Metabolites in Control vs AAKO Mice Fed Chow or HFD

Parameter	Control Chow	AAKO Chow	Control HFD	AAKO HFD
NEFA (mEq/L)	0.55 ± 0.06	0.21 ± 0.04a	0.48 ± 0.03	0.18 ± 0.02a
TAG (mg/mL)	1.01 ± 0.12	0.17 ± 0.02a	1.13 ± 0.10	0.17 ± 0.02a
Ketone bodies (mM)	1.55 ± 0.19	0.49 ± 0.17a	1.52 ± 0.11	0.39 ± 0.03a
Cholesterol (mg/mL)	0.83 ± 0.06	0.62 ± 0.07	1.20 ± 0.09b	0.93 ± 0.08a,b
Glucose (mg/dL)	83 ± 2.8	87 ± 4.2	111 ± 5.2b	91 ± 3.6a
Insulin (ng/mL)	0.58 ± 0.10	0.10 ± 0.06a	1.82 ± 0.28b	0.10 ± 0.06a

Blood energy metabolites in control vs AAKO mice fed chow and HFD (M, 24 wk, fasted 12 h, n = 5–19/group).

^aP < .05 for effect of genotype (ie, AAKO vs control within the same diet group).

^bP < 0.05 for effect of diet (ie, chow vs HFD within the same genotype group).