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. 2014 Dec 12;44(4):1408–1421. doi: 10.1093/ije/dyu192

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© The Author 2014. Published by Oxford University Press on behalf of the International Epidemiological Association

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — The modified familial relative risk, $r_{F}$ , associated with a diseased sibling as a function of r according to formula (2) in the text, where the two individuals in the family have a common risk component that is gamma distributed with shape parameter $δ$ . Here r is the familial relative risk from formula (1), that is the familial relative risk without the skewness introduced by the common, gamma distributed component. $r_{F}$ is plotted for given values of $δ$ . Note that $δ \to \infty$ implies $r_{F} = r$ .