Table 3.

EWAS analyses:^a peripheral blood leukocyte DNA methylation in relation to adiposity phenotypes, the LEAP Project

	Analyses not adjusted for leukocyte distribution	Analyses adjusted for leukocyte distribution
	Omnibus p-valuesb	Omnibus p-valuesb
	Based on permutation test	Based on permutation test
Android:gynoid fat ratio	0.408	0.635
Android fat mass	0.688	0.802
Trunk:limb fat ratio	0.460	0.058
Body mass index	0.738	0.954

^aAnalyses on android fat mass and trunk:limb and android:gynoid fat ratios include 101 participants, whereas analyses on BMI include 106. All analyses adjusted for sex, race (White vs non-White) and current smoking.

^bAnalyses report omnibus p-values based on permutation tests, using the minimum p-value test statistic to construct summary of genome-wide associations. Analyses adjusted for cell mixture are based on the method described in Houseman et al. 2012,³¹ using DNA methylation measures at 100 select DMRs as surrogate markers of leukocyte distribution.