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. 2015 May 12;44(4):1429–1441. doi: 10.1093/ije/dyv041

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© The Author 2015. Published by Oxford University Press on behalf of the International Epidemiological Association

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — DNA methylation variance and correlation can impact EWAS power. Case-control power estimates (A, upper panel) are shown under different pooled SDs and methORs at a fixed mean difference = 10% using parametric (left panel) and nonparametric (right panel) test statistics. MZ twin power estimates (B, lower panel) are shown under different pooled SDs and correlation coefficients at a fixed mean difference = 9% using parametric (left panel) and nonparametric (right panel) test statistics.