Table 1.
Diff |
n = 10 |
n = 15 |
n = 20 |
n = 25 |
n = 30 |
n = 50 |
||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TWIN |
CACO |
TWIN |
CACO |
TWIN |
CACO |
TWIN |
CACO |
TWIN |
CACO |
TWIN |
CACO |
|||||||||||||||
P < 0.05 | P < 10−6 | P < 0.05 | P < 10−6 | P < 0.05 | P < 10−6 | P < 0.05 | P < 10−6 | P < 0.05 | P < 10−6 | P < 0.05 | P < 10−6 | P < 0.05 | P < 10−6 | P < 0.05 | P < 10−6 | P < 0.05 | P < 10−6 | P < 0.05 | P < 10−6 | P < 0.05 | P < 10−6 | P < 0.05 | P < 10−6 | |||
1% | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||
2% | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||
3% | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||
4% | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.9 | 0 | 0 | 0 | ||
5% | 0 | 0 | 0 | 0 | 0.1 | 0 | 0 | 0 | 0.2 | 0 | 0.1 | 0 | 1.4 | 0 | 0 | 0 | 4.4 | 0 | 0 | 0 | 56.0 | 0 | 9.7 | 0 | ||
6% | 0.3 | 0 | 0 | 0 | 1.5 | 0 | 0.1 | 0 | 6.7 | 0 | 0.6 | 0 | 16.1 | 0 | 1.1 | 0 | 35.2 | 0 | 3.5 | 0 | 99.3 | 0 | 85.3 | 0 | ||
7% | 1.9 | 0 | 0.3 | 0 | 6.7 | 0 | 0.6 | 0 | 26.1 | 0 | 3.7 | 0 | 54.2 | 0 | 15.4 | 0 | 79.0 | 0 | 37.7 | 0 | 100 | 0 | 99.9 | 0 | ||
8% | 5.0 | 0 | 0.8 | 0 | 23.1 | 0 | 3.9 | 0 | 54.1 | 0 | 17 | 0 | 82.5 | 0 | 45.3 | 0 | 98.6 | 0 | 80.8 | 0 | 100 | 0 | 100 | 0 | ||
9% | 13.5 | 0 | 2.2 | 0 | 46.2 | 0 | 12.7 | 0 | 80.4 | 0 | 47.1 | 0 | 97 | 0 | 85.1 | 0 | 100 | 0 | 99.4 | 0 | 100 | 0.1 | 100 | 0 | ||
10% | 24.7 | 0 | 8.4 | 0 | 69.5 | 0 | 36 | 0 | 94.8 | 0 | 80.1 | 0 | 100 | 0 | 98.4 | 0 | 100 | 0 | 100 | 0 | 100 | 0.1 | 100 | 0 | ||
12% | 58.0 | 0 | 31.4 | 0 | 94.0 | 0 | 83.6 | 0 | 99.8 | 0 | 99.5 | 0 | 100 | 0 | 100 | 0 | 100 | 0 | 100 | 0 | 100 | 4.8 | 100 | 0.6 | ||
14% | 84.8 | 0 | 66.8 | 0 | 99.7 | 0 | 99 | 0 | 100 | 0 | 100 | 0 | 100 | 0.1 | 100 | 0 | 100 | 0.9 | 100 | 0.1 | 100 | 55.0 | 100 | 25.6 | ||
16% | 95.5 | 0 | 83.3 | 0 | 100 | 0 | 100 | 0 | 100 | 0.2 | 100 | 0 | 100 | 1.7 | 100 | 0 | 100 | 7.4 | 100 | 0.3 | 100 | 99.9 | 100 | 70 | ||
18% | 99.0 | 0 | 97.6 | 0 | 100 | 0 | 100 | 0 | 100 | 0.7 | 100 | 0.1 | 100 | 8.4 | 100 | 0.3 | 100 | 30.4 | 100 | 6.8 | 100 | 100 | 100 | 99.5 | ||
20% | 99.5 | 0 | 99.9 | 0 | 100 | 0.1 | 100 | 0.1 | 100 | 2.8 | 100 | 1.2 | 100 | 16.8 | 100 | 10.3 | 100 | 55.8 | 100 | 42.5 | 100 | 100 | 100 | 100 | ||
25% | 100 | 0 | 100 | 0.1 | 100 | 3.8 | 100 | 4 | 100 | 34.9 | 100 | 38.8 | 100 | 86.5 | 100 | 90.5 | 100 | 99.3 | 100 | 99.4 | 100 | 100 | 100 | 100 | ||
30% | 100 | 0.5 | 100 | 3 | 100 | 25.2 | 100 | 38.6 | 100 | 86.8 | 100 | 94.6 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | ||
30% | 100 | 1.8 | 100 | 13.2 | 100 | 50.5 | 100 | 81.7 | 100 | 97.6 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | ||
55% | 100 | 11.7 | 100 | 52.7 | 100 | 82.2 | 100 | 99.6 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | ||
60% | 100 | 57.6 | 100 | 98.4 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
Diff, mean methylation difference between affected and unaffected individuals; n, sample size (twin pairs or pairs of cases and controls), TWIN, discordant MZ twin design (paired t test); CACO, case-control design (two-sample t test).