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. 2015 Apr 8;44(4):1288–1304. doi: 10.1093/ije/dyv042

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© The Author 2015. Published by Oxford University Press on behalf of the International Epidemiological Association

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — A conceptual framework showing the relationships of interest. GWG and maternal BMI are hypothesized to affect offspring adiposity via offspring DNA methylation. Specific hypotheses are: (i) maternal pre-pregnancy BMI and/or GWG is associated with differential methylation at CpG sites in offspring cord blood; (ii) methylation at these sites is also associated with offspring adiposity (we would also expect consistency between different measures of adiposity and age at measurement); and (iii) maternal adiposity is persistently associated with differential methylation in offspring at time points beyond birth.