Table 3.
Longitudinal analysis of top five sites found differentially methylated in cord blood, between offspring of normal weight and obese mothers
| Gene region (CpG) | Estimated cord blood methylation in offspring of normal weight mothers (%) | Estimated cord blood methylation in offspring of obese mothers (%) | Age 0–7 years: Average yearly change for offspring of normal weight mothers (%) | Age 0–7 years: Average yearly change for offspring of obese mothers (%) | Age 0–7 years: P-value for difference in methylation change | Age 7–17 years: Average yearly change for offspring of normal weight mothers (%) | Age 7–17 years: Average yearly change for offspring of obese mothers (%) | Age 7–17 years: P-value for difference in methylation change |
|---|---|---|---|---|---|---|---|---|
| unnamed (cg00526953) | 70.33 | 66.17 | −2.00 | −1.27 | 0.13 | −0.49 | −0.39 | 0.76 |
| SUCLG2 (cg02321096) | 61.60 | 54.52 | 0.96 | 1.84 | 0.007 | −0.09 | −0.13 | 0.88 |
| FAM129B (cg03270036) | 96.92 | 88.02 | −0.66 | 0.77 | 4.13E-09 | −0.14 | −0.32 | 0.28 |
| KIF15;KIAA1143 (cg17546649) | 9.92 | 14.97 | 0.46 | −0.20 | 0.0003 | 0.01 | 0.00 | 0.90 |
| STAB2 (cg23131355) | 92.73 | 88.21 | 0.10 | 0.68 | 1.29E-05 | −0.07 | −0.07 | 0.96 |