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. 2015 May 27;4(10):e1040214. doi: 10.1080/2162402X.2015.1040214

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Figure 3. — Effects of aerosolized CpG-ODN/Poly(I:C) on the growth of B16 lung metastases and on lung parenchyma of tumor-free mice. (A) Number of macroscopic lung metastases after i.v. injection of B16 melanoma cells in mice untreated (7 mice) or treated with CpG-ODN aerosol (12 mice), Poly(I:C) aerosol (12 mice) orCpG-ODN/Poly(I:C) aerosol (14 mice)*p <0.05; ***p <0.001. (B) Histopathological evaluation of hematoxylin and eosin-stained lung tissue sections from aerosolized CpG-ODN,Poly(I:C),or CpG-ODN/Poly(I:C) mice and untreated mice. Note focal areas of mononuclear and granulocytic infiltrate (magnification x400).