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. 2015 Sep 30;15:393. doi: 10.1186/s12879-015-1133-3

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© Ceccarelli et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Time–kill studies for colistin (COL), meropenem (MEM) and vancomycin (VAN), alone and in combination, against MDR A. baumannii. a The bactericidal activity of COL + VAN is represented. Values in bracket represent the actual concentration (mg/L). b The bactericidal activity of COL + MEM is represented. Values in bracket represent the actual concentration (mg/L). c The bactericidal activity of COL + MEM + VAN is represented. The actual concentrations of the triple combinations are: 0.5 × MIC COL (0.5 mg/L) COL + 0.25 × MIC VAN (32 mg/L) + 0.5 × MIC MEM (64 mg/L) and 0.5 × MIC COL (0.5 mg/L) COL + 0.125 × MIC VAN (16 mg/L) + 0.5 × MIC MEM (64 mg/L). The dashed horizontal line represents a reduction of 3 log10 cfu/mL compared with the initial bacterial count. GC, growth control