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. Author manuscript; available in PMC: 2016 Feb 13.
Published in final edited form as: Nature. 2015 Aug 5;524(7564):180–185. doi: 10.1038/nature14863

Extended figure 5. Axin2 gene dosage and tamoxifen have no effect on pericentral hepatocyte proliferation rate.

Extended figure 5

WT and Axin2CreERT2+/− mice were given EdU daily for seven days. A subset of WT and Axin2CreERT2+/− mice was given 4mg/25gram body weight of tamoxifen daily for 5 days. Pericentral hepatocytes were identified by HNF4α+/GS+ staining. All other hepatocytes were identified by HNF4α+/GS− antibody staining. The EdU positive rates within the two hepatocyte populations as a percentage of total HNF4a+ cells were essentially the same regardless of Axin2 gene dosage or tamoxifen administration. n = 5 animals per group. Data represent mean ± s.e.m. *, **, ***, **** p > 0.05.