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. Author manuscript; available in PMC: 2016 Feb 13.
Published in final edited form as: Nature. 2015 Aug 5;524(7564):180–185. doi: 10.1038/nature14863

Figure 3. Axin2+ hepatocytes proliferate faster than other hepatocytes.

Figure 3

a, Quantification of % EdU+ cells within the Axin2− and Axin2+ hepatocyte populations. Data represent mean ± s.e.m. n = 5 animals. * p < 0.05, two-tailed unpaired t-tests. b, All pericentral hepatocytes are labeled with nuclear GFP in Axin2-rtTA;TetO-H2B-GFP mice given doxycycline for 7 days. c, 14 day chase, d, 28 day chase after doxycycline. e, quantification of GFP labeled nuclei. Data shows individual measurements and the mean. n = 4 animals per group. *, **, *** p < 0.05, two-tailed unpaired t-tests. f, GFP intensity in day 0, day 14 and day 28 chase animals. CV = central vein. PV = portal vein. Scale bars = 100 μm.